The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats |
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| Authors: | Megumi Funakubo Jun Sato Kouei Obata Kazue Mizumura |
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| Institution: | (1) Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan;(2) Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan;(3) R & D Department, Environmental Technology Laboratory, Daikin Industries, Ltd., 1304 Kanaoka-cho, Kita-ku, Sakai-shi, Osaka 591-8511, Japan;(4) Present address: Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; |
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| Abstract: | Complaints of patients with chronic pain may increase when the weather changes. The exact mechanism for weather change-induced
pain has not been clarified. We have previously demonstrated that artificially lowering barometric pressure (LP) intensifies
pain-related behaviors in rats with neuropathic pain chronic constriction injury (CCI) and spinal nerve ligation (SNL)].
In the present study, we examined the rate and magnitude of LP that aggravates neuropathic pain. We measured pain-related
behaviors number of paw lifts to von Frey hair (VFH) stimulation] in awake rats after SNL or CCI surgery, and found that
rates of decompression ≥5 hPa/h and ≥10 hPa/h and magnitudes of decompression ≥5 hPa and ≥10 hPa augmented pain-related behaviors
in SNL and CCI rats, respectively. These results indicate that LP within the range of natural weather patterns augments neuropathic
pain in rats, and that SNL rats are more sensitive to LP than CCI rats. |
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