Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis |
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| Authors: | Zheng Wenjing Gorre Nagaraju Shen Yan Noda Tetsuo Ogawa Wataru Lundin Eva Liu Kui |
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| Affiliation: | 1.Department of Medical Biochemistry & Biophysics, Umeå University, Umeå SE-901 87, Sweden;2.Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 135-8550, Japan;3.Division of Diabetes, Metabolism & Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan;4.Department of Medical Biosciences/Pathology, Umeå University, Umeå SE-901 87, Sweden |
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| Abstract: | Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice. |
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