人类单基因肥胖的遗传学基础

肥胖是一种由遗传因素和环境因素共同作用导致的临床综合征，具有较高的遗传率。目前已经克隆了人类的7个基因，这些单基因突变可以独立地导致人类极度肥胖，其中6个都与食欲的中枢神经系统控制有关，1个与脂肪细胞分化调控有关。深入分析人类肥胖的遗传基础，对于阐明肥胖发生的机理以及对于抗肥胖药物的设计和筛选具有重要意义。

The Genetics of Human Monogenic Obesity

Obesity is a clinical syndrome caused by genetic and environmental factors and has a relatively high heretability.Seven genes,of whose mutations each can independently result in severe human obesity,have been cloned. Six of them are involved in the appetite controlling by the central nervous system,and one is related to the regulation of adipocyte differentiation.Investigations into the genetic basis of human obesity are important for understanding the mechanism of obesity formation and for design and screening of anti-obesity drugs.