Different susceptibility to polycyclic aromatic hydrocarbons (PAH)-induced DNA damage in lung tissue in male and female non-smokers |
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| Authors: | M Lodovici V Akpan C Casalini PDolara |
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| Institution: | Department of Pharmacology and Toxicology, Viale Pieraccini 6, 50139, Florence, Italy. |
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| Abstract: | The levels of benzo(a)pyrene diol-epoxide (BPDE)-DNA adducts and polycyclic aromatic hydrocarbons (PAH) were analysed in a limited number of samples of autoptic lung tissue obtained from non-professionally exposed male (n= 13) and female (n= 12) non-smokers in an attempt to evaluate the relationship between gender, lung PAH levels (n= 25) and susceptibility to BPDE-DNA adduct formation (n= 18). Lung concentrations of chrysene, benzo(g,h,i)perylene and benzo(a)pyrene were significantly higher in males than in females (P |
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| Keywords: | Polycyclic Aromatic Hydrocarbons Bpde-DNA Adducts Human Lung Carcinogenesis |
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