alpha-Fluoro beta alanine in urine of workers occupationally exposed to 5 fluorouracil in a 5 fluorouracil producing factory |
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Authors: | R. P. BOS B. F. J. WEISSENBERGER R. B. M. ANZION |
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Affiliation: | 1. Department of Toxicology, University of Nijmegen, 6500 HB Nijmegen, The Netherlands;2. F. Hoffmann-LaRoche AG, Occupational Health Service, 4070 Basel, Switzerland |
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Abstract: | Because of possible harmful health effects increased attention is being paid to the occupational exposure to cytostatic drugs of workers in hospitals and industry. In this study a biomarker for exposure to 5-fluorouracil (5FU) based on GC-MSMS was applied to study the occupational exposure of four workers in a pharmaceutical factory producing 5FU. The four workers all excreted-fluoro--alanine (FBAL), a metabolite of 5FU, via the urine (range excretion rates: 0-88 9 g per 8h). This is in accordance with the presence of 5FU and/or its precursor ethoxyfluorouracil (EFU) in stationary and personal air wipe samples taken from the the workplace. |
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Keywords: | Biological Monitoring 5-fluorouracil Occupational Exposure Antineoplastic Agents Cytostatic Drugs |
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