Renalase in children with chronic kidney disease

Abstract

Background: Renalase is kidney-derived molecule initially considered as catecholamine-inactivating enzyme. However, recent studies suggest that renalase exerts potent cardio- and nephroprotective actions, not related to its enzymatic activity.

Purpose: To assess renalase level in children with chronic kidney disease (CKD).

Material and methods: Serum renalase, BMI, arterial stiffness, peripheral and central blood pressure, intima-media thickness (IMT), medications, and biochemical parameters were analyzed in 38 children with CKD (12.23?±?4.19?years) (stage G2-5). Control group consisted of 38 healthy children.

Results: In the study group, GFR was 25.74?±?8.94?mL/min/1.73 m²; 6 children were dialyzed; 26 had arterial hypertension. Renalase level was higher in the study group compared to control group (p?<?0.001). In CKD children renalase correlated (p?<?0.05) with BMI Z-score (r?=?–0.36), alfacalcidol dose (r?=?0.41), GFR (r?=?–0.69), hemoglobin (r?=?–0.48), total cholesterol (r?=?0.35), LDL-cholesterol (r?=?0.36), triglycerides (r?=?0.52), phosphate (r?=?0.35), calcium-phosphorus product (r?=?0.35), parathormone (r?=?0.58), and pulse wave velocity Z-score (r?=?0.42). In multivariate analysis GFR (β?=?–0.63, p?<?0.001), triglycerides (β?=?0.59, p?=?0.002), and alfacalcidol dose (β?=?–0.49, p?=?0.010) were determinants of renalase.

Conclusions: In children with CKD there is a strong correlation between renalase level and CKD stage. Furthermore, in these patients renalase does not correlate with blood pressure but may be a marker of arterial stiffness.