| 真核翻译起始因子3与肿瘤 |
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| 引用本文： | 褚丽莎[综述],宋向阳,曹江[审阅]. 真核翻译起始因子3与肿瘤[J]. 国外医学:分子生物学分册, 2010, 0(1): 86-89 |
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| 作者姓名： | 褚丽莎[综述] 宋向阳 曹江[审阅] |
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| 作者单位： | [1]浙江大学附属邵逸夫医院肿瘤外科,杭州市310016 [2]浙江大学邵逸夫临床医学研究所,浙江省生物治疗重点实验室,杭州市310016 |
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| 基金项目： | 浙江省自然科学基金（No.Y207104） |
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| 摘 要： | 真核翻译起始因子3是由多个亚基组成的,在真核翻译起始中发挥重要作用,近年来的研究表明其多个亚基在多种肿瘤细胞中存在异常表达的现象且与肿瘤的侵袭性、转移能力、分化程度及预后相关,使其有望成为肿瘤治疗的新靶点。
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| 关 键 词： | 真核翻译起始因子3 肿瘤 表达 |
Eukaryotic Translation Initiation Factor 3 and Tumor |
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| Affiliation: | CHU Lisha, SONG Xiangyang, CAO Jiang(1 Department of Oucology-Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China 2 Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, 310016, China) |
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| Abstract: | The eukaryotic translation initiation factor 3 （eIF-3） complex consists of multiple subunits and plays an important role in eukaryotic translation initiation. It has been found in recent years that, various subunits of eIF3 are abnormally express in tumors, which is closely related to tumor invasiveness, metastasis, differentiation, and prognosis of cancer. Therefore, cIF-3 may be hopeful as a potential anti-cancer therapeutic target. |
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| Keywords: | eukaryotic translation initiation factor 3 tumor expression |
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