| TLR4信号转导通路在肿瘤中的作用 |
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| 引用本文： | 董宇青,陈玮. TLR4信号转导通路在肿瘤中的作用[J]. 国外医学:分子生物学分册, 2010, 0(5): 448-452 |
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| 作者姓名： | 董宇青 陈玮 |
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| 作者单位： | 浙江大学医学院免疫学研究所,杭州市310058 |
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| 基金项目： | 资助项目：国家自然科学基金（No.30500446） |
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| 摘 要： | 慢性炎症与恶性肿瘤密切相关,Toll样受体4（TLR4）在肿瘤中的广泛表达提示其在慢性炎症致瘤机制中发挥重要作用。活化肿瘤细胞TLR4不仅促进肿瘤的生成和转移,而且参与肿瘤的免疫逃逸。另一方面,免疫佐剂又通过激活免疫细胞的TLR4信号产生抗肿瘤免疫。因此,TLR4在肿瘤中起着双刃剑的作用。
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| 关 键 词： | ToLl样受体4 信号转导通路 脂多糖 |
Role of Toll-Like Receptor 4 Signaling in Tumor |
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| DONG Yuqing,CHEN Wei. Role of Toll-Like Receptor 4 Signaling in Tumor[J]. , 2010, 0(5): 448-452 |
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| Authors: | DONG Yuqing CHEN Wei |
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| Affiliation: | ( Institute of Immunology, Medicine College of Zhejiang University, Hangzhou, 310058, China) |
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| Abstract: | Chronic inflammation was strong associated with malignant tumor. The expression of TLR4 on a wide variety of tumors suggests that TLR4 may play important roles in carcinogenesis and tumor progress during chronic inflammation. Activation of tumor cell TLR4 not only promotes carci- nogenesis and tumor cell metastasis, but also leads to immune evasion of tumor cell. On the other hand, immune adjuvants evoke anti-tumor responses by targeting TLR4 on immune cells. Therefore, TLR4 signaling is a double-edge sword in tumor. |
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| Keywords: | Toll like receptor 4 signaling tranclation lipopoly saccharide |
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