| 朊病毒病相关细胞凋亡 |
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| 引用本文： | 韩彦玲,韩俊,李朝品,董小平. 朊病毒病相关细胞凋亡[J]. 国外医学:分子生物学分册, 2010, 0(3): 247-250 |
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| 作者姓名： | 韩彦玲 韩俊 李朝品 董小平 |
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| 作者单位： | [1]安徽理工大学医学院,安徽省淮南市232001 [2]中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室,北京市100052 |
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| 基金项目： | 国家自然科学基金（No.30771914,30800975）,传染病重大专项（No.2009ZX10004-101,2008ZX10004-001,2008ZX10004-002）,科研院所技术开发研究专项资金（No.2008EG150300）,重点实验室发展基金（No.2008SKLID102,2008SKLID202） |
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| 摘 要： | 朊病毒病是一组蛋白质折叠异常的蛋白质构象病,由正常朊蛋白PrP^C转化为具蛋白酶抗性的异常朊蛋白PrP^Sc并在中枢神经系统聚集引起.其主要的病理变化为神经元的丢失,脑组织的海绵样变及神经胶质细胞增生.目前认为其神经元丢失的主要原因为凋亡及自噬等,而神经元的凋亡涉及多种因素及途径,机制较为复杂.对神经元凋亡的研究将有助于揭示朊病毒病的发病机制.
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| 关 键 词： | 朊病毒病 神经元 凋亡 |
Cell Apoptosis Associated with Prion Diseases |
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| HAN Yanling,HAN Jun,LI Chaopin,DONG Xiaoping. Cell Apoptosis Associated with Prion Diseases[J]. , 2010, 0(3): 247-250 |
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| Authors: | HAN Yanling HAN Jun LI Chaopin DONG Xiaoping |
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| Affiliation: | 1Medical School, Anhui University of Science and Technology, Huainan, Anhui, 232001, China ;2 State Key Laboratory for Infections Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100052, China) |
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| Abstract: | Prion diseases are a group of protein conformational diseases attributable to inaccurate protein folding. They are caused by the accumulation of the abnormal protease resistant prion protein （PrP^Sc） from the post-translational conversion of the normal host-encoded PrP^C in the central nervous system （CNS） . Prion diseases are characterized by neuronal loss, spongiosis, reactive astrocytosis, and microgliosis. At present it is thought that the main cause of neuronal loss is apoptosis and autophagy, while neuronal apoptosis is associated with many factors and pathways. The study of neuronal apoptosis contributes to the unearthing of the mechanism of prion diseases. |
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| Keywords: | prion diseases neurons apoptosis |
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