FGF21对能量代谢的调控 |
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引用本文: | 周博[综述] 孙宏志[审阅]. FGF21对能量代谢的调控[J]. 国外医学:分子生物学分册, 2010, 0(3): 263-266 |
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作者姓名: | 周博[综述] 孙宏志[审阅] |
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作者单位: | 西安交通大学医学院临床病理生理学研究所,西安市710061 |
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摘 要: | 成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)作为一种不依赖胰岛素的血糖调节因子,目前已被看做是治疗2型糖尿病的一个潜在的新型治疗因素.大量鼠类及灵长类动物模型的实验结果显示:FGF21可通过作用于脂肪组织及胰腺来降低血糖和甘油三酯含量,从而预防饮食诱导的肥胖及胰岛素抵抗.此外,FGF21也被证明可作为一种主要的内源性调控子,在禁食和酮症时起着关键的调控作用.然而,一些临床观察实验的结果表明,临床观察实验与动物模型实验之间虽然具有一定的相似性,但也存在很多不同,因而目前FGF21在人体中的生理学作用仍不明确.
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关 键 词: | 成纤维细胞生长因子21 能量代谢 肥胖症 糖尿病 |
Regulation of Energy Metabolism by FGF21 |
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Affiliation: | ZHOU Bo, SUN Hongzhi (Institute of Clinical Pathophsiology, School of Medicine, Xi' an Jiaotong University, Xi' an, 710061, China) |
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Abstract: | Fibroblast growth factor 21 ( FGF21 ) is a factor regulating blood glocose independently on insulin, thus considered as a novel putative therapeutic agent for type 2 diabetes. A large amount of data, obtained from murine models and non-human primates, have showed that FGF21 can lower blood glucose and triglyceride levels via its effects on adipose tissue and pancreas, protecting against diet-induced obesity (DIO) and insulin resistance. Furthermore, FGF21 has also been proposed to play an important role in physiological response to starvation and ketosis, as a major endocrine regulator. The results from clinical observational studies and animal models studies displayed some similarities, but also differences, thus making the physiological role of FGF21 in man still unclear. |
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Keywords: | FGF21 energy metabolism diabetes obesity |
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