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Dual binding site inhibitors of B-RAF kinase |
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| Authors: | Wolin Ronald L Bembenek Scott D Wei Jianmei Crawford Shelby Lundeen Katherine Brunmark Anders Karlsson Lars Edwards James P Blevitt Jonathan M |
| Institution: | aJohnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA |
| Abstract: | Computer aided modeling guided the design of a series of diarylimidazole compounds (11–22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated. |
| Keywords: | B-RAF Kinase inhibitors Diarylimidazoles |
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