| 慢性温和不可预知性刺激致大鼠抑郁症模型的病理机制研究进展 |
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| 引用本文： | 赵瑞,杜冠华.慢性温和不可预知性刺激致大鼠抑郁症模型的病理机制研究进展[J].中国实验动物学杂志,2011(10):141-143,149. |
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| 作者姓名： | 赵瑞 杜冠华 |
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| 作者单位： | 中国医学科学院北京协和医学院,药物研究所国家药物筛选中心,北京100050 |
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| 基金项目： | 国家科技重大专项--重大新药创新. |
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| 摘 要： | 抑郁症是一种伴有行为学、神经化学和其他生理病理导演的心理障碍.慢性暴露于轻度不可预见性应激（CUMS）已被证实可以导致抑郁薅行为,包括糖水消耗减少等.并且CUMS引起的一系列生化改变类似于人类的抑郁症.我们综述了CUMS致抑郁症动物模型的病理变化,包括了受体、信号转导系统等方面的病理改变.
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| 关 键 词： | 慢性温和不可预知性刺激 病理改变 受体 信号转导 |
Pathological Mechanism Research in Chronic Unpredictable Mild Stress of Rats |
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| Institution: | ZHAO Rui,DU Guau-hua (Chinese Academy of Medical Sciences ＆ Peking Union Medical College( PUMC), Institute of Materia Medica (IMM), national center for pharmaceutical screening (NCPS) , Beijing 100050, China) |
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| Abstract: | Depression is a psychological disorder characterized by behavioral, neurochemical and other physiological abnormities. Chronic exposure to mild unpredictable stress （CUMS） has previously been found to cause an antidepressant-reversible decrease in the consumption of palatable sweet solutions, at the same time biochemical disturbances induced by the CUMS procedure were similar to those found in human depression. We review the pathological changes of the animal model of depression （CUMS）. it reflected in some persistent molecular pathologys, such as the changes in receptor ,signal transduetion. |
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| Keywords: | CUMS Pathological changes Receptor Signal transduetion |
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