Somatostatin-14 and -28 in the male rat reproductive system |
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| Authors: | A E Pekary T Yamada B Sharp S Bhasin R S Swerdloff J M Hershman |
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| Institution: | 1. Endocrinology and Gastroenterology Research Laboratories, Medical and Research Services, Veterans Administration Medical Center West Los Angeles, USA;2. Wadsworth Division and Department of Medicine, University of California, Los Angeles, Calif. 90073, USA |
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| Abstract: | Somatostatin-14 (SRIF-14) has been shown to occur throughout the male rat reproductive system by SRIF radioimmunoassay, Sephadex G-50 exclusion chromatography, and parallel line analysis. SRIF-28 was found only in the epididymis. The highest concentrations of total SRIF-like immunoreactivity (SLI), representing the combined concentrations of SRIF-14 and SRIF-28, were measured in the prostates of 1 1/2- and 3-month-old Sprague-Dawley rats. The levels of SLI in prostates from 9-month-old males were about 10% that of the younger animals. Dilution curves for extracts of all reproductive tissues were parallel with synthetic SRIF-14. |
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