Identification and characterization of normal length nonfluorescent Y chromosomes: cytogenetic analysis,Southern hybridization and non-isotopic in situ hybridization |
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| Authors: | Frank Speleman Bart Van der Auwera Kathelijne Mangelschots Miet Vercruyssen Ton Raap Joop Wiegant Margarita Craen Jules Leroy |
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| Affiliation: | (1) Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium;(2) Department of Pediatrics, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium;(3) Department of Medical Genetics, University of Antwerp, B-2610 Wilrÿk, Belgium;(4) Department of Cytochemistry and Cytometry, University of Leiden, NL-2333 AL Leiden, The Netherlands |
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| Abstract: | Summary In two female patients with a 45,X/46,X,+mar karyotype the marker chromosomes were identified as normal length nonfluorescent Y chromosomes (nlYnf) using non-isotopic in situ hybridization (NISH) complementary to routine cytogenetic analysis and Southern hybridization. The recognition of the nlYnf as isodicentric in both patients illustrates and confirms the usefulness and importance of NISH in the identification and characterization of this and many other types of complex chromosome rearrangements. |
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