Structural approach of the mechanism of inhibition of alpha-chymotrypsin by coumarins |
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| Authors: | Wouters Johan Huygens Marjorie Pochet Lionel Pirotte Bernard Durant François Masereel Bernard |
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| Affiliation: | Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 rue de Bruxelles, B-5000 Namur, Belgium. |
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| Abstract: | A pharmacophore associated to the inhibiton of alpha-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives. |
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