Cystatin, a protein inhibitor of cysteine proteases alters viral protein cleavages in infected human cells |
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| Authors: | B D Korant J Brzin V Turk |
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| Affiliation: | 1. Central Research and Development Department Experimental Station E. I. du Pont de Nemours & Company, Inc. Wilmington, Delaware 19898, USA;2. Josef Stefan Institute Department of Biochemistry Jamova 39 61111 Ljubljana, Yugoslavia |
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| Abstract: | Chicken cystatin is a previously described small protein which has the property of inhibiting cysteine active site proteases. The protein, when added to cultured human cells, alters the intracellular proteolytic processing of poliovirus proteins, and causes a reduction in virus yield. It is suggested that the cystatin is able to penetrate to the cellular cytoplasm and inhibit the action of the poliovirus protease. |
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