Demonstration of the simultaneous presence of transferrin, hemopexin and albumin in the same adult rat hepatocyte. |
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| Authors: | J Foucrier M Kraemer J Vassy M T Chalumeau |
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| Affiliation: | 1. Coordinating Center for Alpha1-Antitrypsin Deficiency-Related Liver Disease of the European Reference Network “Rare Liver” and the European Association for the Study of the Liver Registry Group “Alpha1-Liver,” University Hospital Aachen, Aachen, Germany;2. Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany;3. Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria;4. Department of Gastroenterology, Centro Hospitalar do Funchal, Madeira, Portugal;5. Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark;6. Liver Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain;7. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain;8. Department of Hepatology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK;9. Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany;10. Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany;11. Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria;12. Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria;13. Department of Medicine I, Charité–Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany;14. Gastroenterology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal;15. Gastroenterology Department, Centro Hospitalar de São João, Faculty of Medicine of Porto University, Porto, Portugal;16. Gastroenterology Department, Centro Hospitalar do Porto, Porto, Portugal;17. Gastroenterology Department, Hospital de Braga, Braga, Portugal;18. Gastroenterology Department, Hospital Universitário de Coimbra, Coimbra, Portugal;19. Medical Care Centre, Dr Stein and Colleagues, Moenchengladbach, Germany;20. Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany;21. Jülich Aachen Research Alliance-Brain, Aachen, Germany;22. Clinic for Pulmonology, Leiden University Medical Center, Leiden, The Netherlands;23. Clinic for Pulmonology, University Hospital Frankfurt, Frankfurt, Germany;24. Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany;25. Department of Respiratory Medicine, Cambridge National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK;26. Department of Medicine V, Saarland University Medical Center, Saarland University, Homburg, Germany;27. Clinic for Pneumology, Marburg University Hospital, Marburg, Germany;28. Institute for Pulmonary Rehabilitation Research, Schoen Clinic Berchtesgadener Land, Member of the Deutsches Zentrum für Lungenforschung, Schönau am Königssee, Germany;29. Department of Pneumology, Vall d''Hebron University Hospital, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Barcelona, Spain;30. Clinic for Pneumology, German Center for Lung Research, Medical University Hannover, Hannover, Germany;31. Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland;1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210023, China;3. Department of Pathology, School of Medicine, Saint Louis University, MO 63104, USA;4. Shandong University of Traditional Chinese Medicine, Jinan 250035, China |
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| Abstract: | The location of three plasma proteins (transferrin, hemopexin, and albumin) in hepatocytes was investigated in adult rats. The synthesis of transferrin anf hemopexin has been established by ultrastructural studies showing a labeling of the rough endoplasmic reticulum (RER). By using an indirect immunoenzymatic method with monospecific antibody solutions, the three proteins were detected in the same hepatocyte. The simultaneous presence of different plasma proteins in hepatocytes seems to point to the fact that the synthesis in these cells could be a non-specialized type. |
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