Dietary Inflammatory Index,Alternative Healthy Eating Index-2010, Mediterranean Diet Score and the risk of pancreatic cancer |
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| Affiliation: | 1. Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, VIC 3004, Australia;2. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie St, Carlton, VIC 3010, Australia;3. Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene St., Columbia, SC 29208, USA;4. Department of Nutrition, Connecting Health Innovations LLC, 1417 Gregg St., Columbia, SC 29201, USA;5. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, 246 Clayton Rd, Clayton, VIC 3168, Australia;1. Univ. Bordeaux, Gironde General Cancer Registry, 33000 Bordeaux, France;2. Inserm, Bordeaux Population Health, Research Center U1219, Team EPICENE, 33000 Bordeaux, France;3. Centre Régional de Coordination du Dépistage des Cancers (CRCDC), Nouvelle Aquitaine, France;4. Loire-Atlantique/Vendée Cancer Registry, Nantes, France;5. CERPOP, Université de Toulouse, Toulouse, France;6. FRANCIM Network of French Cancer Registries, France;7. Breast and Gynaecologic Cancer Registry of Côte d’Or, Georges Francois Leclerc Comprehensive Cancer Centre, INSERM U1231, 1 rue Professeur Marion, Dijon, France;8. Epidemiology and Quality of Life Research Unit, INSERM U1231, Dijon, France;9. Institut Bergonie, Inserm CIC 1401, Clinical and Epidemiological Research Unit, 351 cours de la Libération, 33405 Talence cedex, France;1. Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA;2. Office of Clinical Research, Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA;3. Department of Radiation Oncology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199 USA;4. Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199 USA;1. Department of Gastroenterology, Mater Misericordiae University Hospital, Dublin, Ireland;2. School of Medicine, University College Dublin, Ireland;3. Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland;4. Department of Pathology, Mater Misericordiae University Hospital, Dublin, Ireland;5. Department of Pathology, St Vincent’s University Hospital, Dublin, Ireland;6. Department of Colorectal Surgery, St Vincent’s University Hospital, Dublin, Ireland;1. Hungarian National Cancer Registry and National Tumorbiology Laboratory, National Institute of Oncology, Budapest, Hungary;2. Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France;3. Department of Molecular Immunology and Toxicology and National Tumorbiology Laboratory, National Institute of Oncology, Budapest, Hungary;1. Research Unit for General Practice, Aarhus, Bartholins Alle 2, 8000 Aarhus C, Denmark;2. Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus C, Denmark |
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| Abstract: | BackgroundPrevious studies of dietary patterns and pancreatic cancer risk have been inconclusive; we aimed to investigate the association of Mediterranean Diet Score (MDS), Alternative Healthy Eating Index-2010 (AHEI-2010), and Dietary Inflammatory Index (DII®) with risk of pancreatic cancer.MethodsWe used data from the Melbourne Collaborative Cohort Study including 33,690 men and women aged 40–69 years at recruitment in 1990–1994. A total of 258 incident cases of pancreatic cancer was identified over an average of 23.7 years of follow-up. Hazard ratios (HR) were estimated using Cox regression, with age as the underlying time metric, adjusting for potential confounders including sex, height, country of birth, education, socio-economic position, physical activity, energy intake, smoking status, pack-years smoking, years since quitting smoking, and alcohol intake.ResultsA healthier diet as assessed by the AHEI-2010 was associated with a lower risk of pancreatic cancer [HRQuartile4 vs Quartile1 = 0.58; 95%CI 0.40 – 0.85; p for trend 0.003]. Weaker but consistent evidence was observed for the other indexes [DII® HRQuartile4 vs Quartile1 = 1.30; 95%CI 0.82 – 2.06; p for trend 0.1], [MDS HRCategory3 vs Category1 = 0.79; 95%CI 0.49 – 1.26; p for trend 0.06].ConclusionAdherence to a healthier diet, as assessed by the AHEI-2010, may reduce the risk of pancreatic cancer. |
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| Keywords: | Diet Inflammation Pancreatic cancer Prospective cohort Epidemiology |
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