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Identification of XAF1 as an endogenous AKT inhibitor
Institution:1. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;2. Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China;3. University of Chinese Academy of Sciences, Number 19A Yuquan Road, Beijing 100049, China;4. CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China;5. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, National Center for Protein Science Shanghai, 333 Haike Road, Shanghai 201210, China;6. Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China;7. Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China;8. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;9. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China;10. School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai 201210, China
Abstract:
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  • Keywords:AKT  XAF1  phosphorylation  ubiquitination  FOXO1  metabolism  prostate cancer  CP: Cell biology
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