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Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
Affiliation:1. Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), and DKFZ-ZMBH Alliance, Heidelberg, Germany;2. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany;3. Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany;4. Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland;5. Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany;6. Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany;7. Center for Organoid Systems (COS), Technical University of Munich (TUM), Garching, Germany;8. Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich (TUM), Garching, Germany;9. Division of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilian University of Munich (LMU), Munich, Germany;10. Institute of Pathology, Technical University of Munich (TUM), Munich, Germany;11. Institute for Lung Health and Immunity (LHI) and Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany;12. Institute for Lung Research, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany;13. Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany;14. Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;15. Institute of Human Genetics, Helmholtz Center Munich, Neuherberg, Germany;16. Department of Gynaecology and Obstetrics, University Women’s Clinic, University Medical Centre Mannheim, Mannheim, Germany;17. National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany;18. German Cancer Consortium (DKTK), Germany
Abstract:
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  • Keywords:EPCAM  EMT  ZEB1  GRHL2  breast cancer  metastasis  intratumor heterogeneity  CP: Cancer
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