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Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain
Affiliation:1. Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35025, USA;2. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA;3. Department of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan 430056, China;4. Department of Pain Medicine, Anesthesiology, Critical Care and Pain Medicine Division, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;5. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA;1. Developmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine, Berlin, Germany;2. NeuroCure Cluster of Excellence, CharitéUniversitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany;3. Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany;4. Department of Otolaryngology - Head & Neck Surgery, University of Missouri School of Medicine, Columbia, MO, USA;5. The First Affiliated Hospital, Jinan University, Guangzhou, China;6. Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;7. Development and Function of Neural Circuits, Max Delbrück Center for Molecular Medicine, Berlin, Germany;8. Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine, Berlin, Germany;9. Systems Biology Imaging, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany;10. Institut de Biologie de l’ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France;11. Genome Engineering & Disease Models, Max Delbrück Center for Molecular Medicine, Berlin, Germany;12. Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine, Berlin, Germany;1. Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, MO 63110, USA;2. Department of Pathology and Immunology, Division of Immunobiology, Washington University in St. Louis, St. Louis, MO 63110, USA;3. Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22903, USA;4. Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland 1023, New Zealand;5. Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA;6. Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil;1. Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK;2. Adam Smith Business School, University of Glasgow, Glasgow G12 8QQ, UK;1. Department of Physiology, University of California, San Francisco, San Francisco, CA, USA;2. Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA;3. University of Cambridge, Cambridge, UK;4. National Institute of Mental Health, Bethesda, MD, USA;1. UCL Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London W1T 4JG, UK;2. UCL Gatsby Computational Neuroscience Unit, London W1T 4JG, UK;1. Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;2. Graduate Program in Biological and Biomedical Sciences, University of Southern California, Los Angeles, CA 90089, USA;3. Center for Neural Circuits and Sensory Processing Disorders, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;4. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Abstract:
Keywords:neuropathic pain  spinal dorsal horn neurons  actin cytoskeleton  dendritic spines  structural synaptic plasticity  functional synaptic plasticity  NMDAR  Rho GTPase  Tiam1
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