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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
Affiliation:1. Department of Radiation Oncology, Ohio State Comprehensive Cancer Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, OH 43210, USA;2. Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA;3. College of Medicine at The Ohio State University, Columbus, OH 43210, USA;4. Human Nutrition Unit, French National Research Institute for Agriculture, Food and Environment, University Clermont Auvergne, 63122 Clermont-Ferrand, France;5. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA;6. Department of Neurology (Neuro-Oncology), David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA;7. Department of Pathology and Laboratory Medicine, School of Medicine at University of California, Irvine, CA 92617, USA;8. Center of Cancer Metabolism, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
Abstract:
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  • Keywords:SREBP-1  cholesteryl esters  lipid droplets  autophagy  ATG9B  ATG4A  LC3B  NPC2  cholesterol homeostasis  glioblastoma  CP: Metabolism  CP: Cancer
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