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Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment
Affiliation:1. Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland;2. Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland;3. Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland;4. CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland;5. Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK;6. Laboratory for Haematology and Immunology (HEIM), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium;7. Department of Colorectal Surgery, Galway University Hospital, Galway, Ireland;8. Palleon Pharmaceuticals, Waltham, MA 02451, USA;9. Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland;10. Discipline of Pathology, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland;11. Cancer Research UK Beatson Institute, Glasgow, UK;12. Blood Cancer Network of Ireland (BCNI), Galway, Ireland;13. Department of Hematology, Galway University Hospital, Galway, Ireland
Abstract:
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  • Keywords:stromal cells  cancer-associated fibroblasts  sialylation  siglecs  inflammation  colon cancer  tumor microenvironment  T cells  T cell exhaustion  immunotherapy  CP: Immunology  CP: Cancer
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