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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing
Institution:1. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;4. Cologne Center for Genomics, University of Cologne, 51149 Cologne, Germany;5. Genomic Medicine Institute, Lerner Research Institute, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA;6. Department of Neurology, McGovern Medical School, UTHealth, Houston, TX 77030, USA
Abstract:
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  • Keywords:voltage-gated sodium channel  base editing  CRISPR  variants to function  electrophysiology  channelopathy  neurodevelopmental disorder  mutational screening  ion channels  NaV1  2  CP: Neuroscience
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