Rescue effect of curcumin against copper toxicity |
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| Institution: | 1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Immunology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran;3. University of Debrecen, Medical School Hungary, Egyetem tér 1, Debrecen;4. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India;7. Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai 602105, India;8. University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India;9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;11. School of Medicine, The University of Western Australia, Perth, Australia;12. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Neurosurgery, 5th Military Clinical Hospital with the SP ZOZ Polyclinic in Krakow, 30-901 Krakow, Poland;2. Department of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, 41-800 Zabrze, Poland;3. Department of Neurosurgery, St. Raphael Hospital, 30-693 Krakow, Poland;4. Department of Neurosurgery, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, 30-705 Kraków, Poland;5. Department of Agricultural and Environmental Chemistry, University of Agriculture in Krakow, 31-120 Krakow, Poland;6. Department of Trauma and Orthopedic Surgery, 5th Military Clinical Hospital, Kraków, Poland;7. Department of Rehabilitation in Orthopedics, Faculty of Motor Rehabilitation Bronis?aw Czech University of Physical Education in Kraków, Poland;8. Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland;9. Department of Neurosurgery, Provincial Specialist Hospital No. 2 in Jastrz?bie-Zdrój, 44-300 Jastrz?bie-Zdrój, Poland;1. Nuclear Energy Center for Agriculture, University of São Paulo, Avenida Centenário 303, 13416-000 Piracicaba, SP, Brazil;2. College of Agriculture Luiz de Queiroz, University of São Paulo, Avenida Pádua Dias 11, 13418-900 Piracicaba, SP, Brazil;1. Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany;2. Department of Molecular Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Str. 24, Jena 07743, Germany;3. TraceAge, DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Potsdam, Jena, Berlin, Germany;4. German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, Berlin 10589, Germany;1. Av. Ciudad Universitaria 3000, C.P. 04510, Coyoacan, Mexico City, Mexico;2. Department of Cellular and Tissue Biology, School of Medicine, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;3. Posgrado en Ciencias Biologicas, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;4. Department of Microbiology and Parasitology. School of Medicine, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;1. Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China;2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China;1. Graduate Group of Nutritional Biology, Department of Nutrition, University of California at Davis, One Shields Ave., Davis, CA 95616, USA;2. USDA/ARS/Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA;3. Department of Pathology and Laboratory Medicine, University of California at Davis, 2805 50th Street, Sacramento, CA 95817, USA |
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| Abstract: | Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives (i.e. diacetylcurcumin (DAC) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. The aforementioned properties have put curcumin on spotlight as a potential treatment for ailments such as, hepatic diseases, neurodegenerative diseases, metabolic syndrome, dyslipidemia, cardiovascular disease, auto-immune diseases, malignancies and conditions associated with metal overload. Copper is essential for major biological functions, however, an excess causes chronic ailments including neurodegenerative disorders. The fascinating approach of curcumin could alleviate such effect by forming a complex. Thus, this review aims to present available data on the effect of copper-curcumin interaction in various in vitro, ex-vivo in vivo, and clinical studies. |
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| Keywords: | Turmeric Wounds Curcuminoids Heavy metals Antioxidant Anti-inflammatory Curcumin Hepatic diseases Neurodegenerative diseases Cardiovascular disease Copper-curcumin interaction |
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