Assessment of trace elements in critically ill patients with systemic inflammatory response syndrome: A systematic review |
| |
| Institution: | 1. Graduate Program in Nutrition, Federal University of Santa Catarina, Santa Catarina, Brazil;2. Discipline of Nutrition and Metabolism, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil;3. Department of Pediatrics, Hospital Geral de Itapecerica da Serra—HGIS, Itapecerica da Serra, São Paulo, Brazil;1. Environmental Health Sciences Division, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA;2. Saba University School of Medicine, Caribbean, the Netherlands;3. Center for Environmental Occupational Risk Analysis and Management College of Public Health, University of South Florida, Tampa, FL, USA;4. Stantec (Cardno ChemRisk), Boston, MA, USA;5. Saint Francis Hospital and Medical Center; Hartford, CT, USA;6. School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, China;7. Department of Biomedical and Biotechnological Sciences; School of Medicine University of Catania, Via Santa Sofia 97, Catania 95123, Italy;1. National Institute of Occupational Health, 0363 Oslo, Norway;2. Technical University of Darmstadt, Institute of Applied Geosciences, 64287 Darmstadt, Germany;3. Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Sweden;1. Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand, India;2. Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Uttarakhand, India;1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Immunology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran;3. University of Debrecen, Medical School Hungary, Egyetem tér 1, Debrecen;4. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India;7. Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai 602105, India;8. University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India;9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;11. School of Medicine, The University of Western Australia, Perth, Australia;12. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China;2. Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Heilongjiang Provincial Key Lab of Trace Elements and Human Health, Harbin Medical University, Harbin 150081, Heilongjiang, China;3. Department of Public Health, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;4. Institute for Endemic Disease Prevention and Treatment of Shandong Province, Jinan 250014, Shandong, China |
| |
| Abstract: | BackgroundZinc (Zn), copper (Cu), and selenium (Se) are involved in immune and antioxidant defense. Their role in systemic inflammatory response syndrome (SIRS) treatment and outcomes remains unclear. This systematic review aimed to describe trace element concentrations in different types of biological samples and their relationship with morbidity and mortality in patients with SIRS. Methods: Literature was systematically reviewed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The search results were screened and evaluated for eligibility, and data were extracted and summarized in tables and figures. Results: Most of the 38 included studies evaluated Se (75%), followed by Zn (42%) and Cu (22%). Plasma was the main biological sample evaluated (58%). Thirteen studies found lower plasma/serum concentrations of Zn, Se, and Cu in SIRS patients than in controls upon admission, 11 studies on adults (intensive care unit-ICU) and two in pediatric ICU (PICU). Three ICU studies found no difference in erythrocyte trace element concentrations in patients with SIRS. In all studies, the two main outcomes investigated were organ failure and mortality. In seven ICU studies, patients with lower plasma or serum Zn/Se levels had higher mortality rates. A study conducted in the PICU reported an association between increased Se variation and lower 28-day mortality. In an ICU study, lower erythrocyte selenium levels were associated with higher ICU/hospital mortality, after adjustment. Five ICU studies associated lower plasma/serum Zn/Se levels with higher organ failure scores and one PICU study showed an association between higher erythrocyte Se levels and lower organ dysfunction scores. Conclusion: There was no difference in erythrocyte Se levels in patients with SIRS. Serum/Plasma Zn and serum/plasma/erythrocyte Se are associated with organ dysfunction, mortality, and inflammation. Trace element deficiencies should be diagnosed by erythrocyte, or complementary measurements in the presence of inflammation. |
| |
| Keywords: | Systemic Inflammatory Response Syndrome Zinc Copper Selenium Clinical outcomes Critical illness |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
