Interaction between mitophagy,cadmium and zinc |
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| Affiliation: | 1. M.V. Lomonosov Moscow State University, Moscow, Russia;2. Research Center of Neurology, Moscow, Russia;1. Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt;2. Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University, P.O. Box, 90950, Riyadh 11623, Saudi Arabia;3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt;1. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran;2. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran;3. Gastrointestinal & Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran;4. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;5. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK;6. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran;1. Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil;1. Spectrometry, Sample Preparation and Mechanization Group, Institute of Chemistry, University of Campinas, Unicamp, P.O. Box 6154, Campinas, SP 13083-970, Brazil;2. National Institute of Science and Technology for Bioanalytics, Institute of Chemistry, University of Campinas, Unicamp, P.O. Box 6154, Campinas, SP 13083-970, Brazil;1. Servicio de Pediatría Hospital, Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;2. Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;3. Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;4. Unidad de investigación. Servicio de Medicina Preventiva, Hospital Clínico San Carlos, Madrid, Spain;5. Hospital Universitario de la Zarzuela, Madrid, Spain;6. Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;1. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, PR China;2. School of Medicine, and Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, PR China;3. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China |
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| Abstract: | Mitophagy is the selective degradation of mitochondria by autophagy. This process is considered to be one of the stages of mitochondrial quality control, as a result of which damaged depolarized mitochondria are eliminated, thus limiting the formation of reactive oxygen species and the release of apoptogenic factors. Selective degradation of mitochondria by autophagy is one of the main ways to protect cells from cadmium toxicity, which results in dysfunction of the mitochondrial electron transport chain, leading to electron leakage, production of reactive oxygen species and cells death. However, excessive autophagy can be dangerous for cells. Currently, the participation of cadmium ions in normal physiological processes has not been detected. Zn2+, unlike Cd2+, regulate the activity of a large number of functionally important proteins, including transcription factors, enzymes, and adapters. It has been shown that Zn2+ not only participate in autophagy, but are also crucial for basal or induced autophagy. It is likely that zinc drugs can be used to reduce the cadmium toxicity and in the regulation of mithophagy. |
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| Keywords: | Mitophagy Zinc ions Cadmium ions Mitochondria |
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