Dynamics of epigenetic control in plants via SET domain containing proteins: Structural and functional insights |
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| Institution: | 1. National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi 110067, India;2. Department of Plant Sciences, University of Hyderabad, Hyderabad, Telangana 500046, India;1. Department of Agricultural Biotechnology, CSK Himachal Pradesh Agricultural University, Palampur 176 062 HP, India;2. Department of Botany, Panjab University, Chandigarh, India;1. School of Medicine, Guizhou University, Guiyang 550025, China;2. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;3. Department of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;4. Cancer Center, Shanghai Tenth People''s Hospital, School of Medicine, Tongji University, Shanghai 200040, China;5. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China;1. Department of Cell Biology and Genetics, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China;2. State Key Laboratory of Proteomics, Beijing Proteome Reesearch Center, National Center for Protein Sciences Beijing, Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing 102206, China;3. Anhui Medical University School of Basic Medicine, Hefei 230032, Anhui, China;4. Department of Biomedicine, School of Medicine, Guizhou University, Guiyang 550025, China;5. Department of Toxicology, School of Public Health, China Medical University, Shenyang, 110122, PR China |
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| Abstract: | Plants control expression of their genes in a way that involves manipulating the chromatin structural dynamics in order to adapt to environmental changes and carry out developmental processes. Histone modifications like histone methylation are significant epigenetic marks which profoundly and globally modify chromatin, potentially affecting the expression of several genes. Methylation of histones is catalyzed by histone lysine methyltransferases (HKMTs), that features an evolutionary conserved domain known as SET Su(var)3–9, E(Z), Trithorax]. This methylation is directed at particular lysine (K) residues on H3 or H4 histone. Plant SET domain group (SDG) proteins are categorized into different classes that have been conserved through evolution, and each class have specificity that influences how the chromatin structure operates. The domains discovered in plant SET domain proteins have typically been linked to protein-protein interactions, suggesting that majority of the SDGs function in complexes. Additionally, SDG-mediated histone mark deposition also affects alternative splicing events. In present review, we discussed the diversity of SDGs in plants including their structural properties. Additionally, we have provided comprehensive summary of the functions of the SDG-domain containing proteins in plant developmental processes and response to environmental stimuli have also been highlighted. |
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