Selenium,selenoproteins and cancer of the thyroid |
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| Affiliation: | 1. Faculty of Health Sciences, University Fernando Pessoa, 4249-004 Porto, Portugal;2. Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain;1. School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, PR China;2. Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, PR China;1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China;2. Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Heilongjiang Provincial Key Lab of Trace Elements and Human Health, Harbin Medical University, Harbin 150081, Heilongjiang, China;3. Department of Public Health, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;4. Institute for Endemic Disease Prevention and Treatment of Shandong Province, Jinan 250014, Shandong, China;1. Pontifical Catholic University of Rio Grande do Sul, PUCRS, School of Health and Life Sciences, Post-Graduate Program in Dentistry, Porto Alegre, RS, Brazil;2. Pontifical Catholic University of Rio Grande do Sul, PUCRS, School of Medicine, Post-Graduate Program in Medicine and Health Sciences, Porto Alegre, RS, Brazil;3. Nutrition Thinking® Co., Tecnopuc, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil;1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China;2. Hebei Key Laboratory of Reproductive Medicine, Hebei Institute of Reproductive Health Science and Technology, Shijiazhuang 050071, China;1. Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Anatomía Patológica, Buenos Aires, Argentina, M. T. de Alvear 2142, 2° A, C1122AAH Buenos Aires, Argentina;2. Becario de Investigación de la Universidad de Buenos Aires, Buenos Aires, Argentina;3. Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Estomatología, Buenos Aires, Argentina, M. T. de Alvear 2142, 2° A, C1122AAH Buenos Aires, Argentina;4. Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, San Martín, Buenos Aires, UNSAM Campus Miguelete, 25 de Mayo y Francia, San Martín, B1650HMN Buenos Aires, Argentina;5. CONICET - Universidad Nacional de San Martín, Instituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), San Martín, Buenos Aires, UNSAM Campus Miguelete, 25 de Mayo y Francia, San Martín, B1650HMN Buenos Aires, Argentina;6. Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Histología y Embriología, Buenos Aires, Argentina, M. T. de Alvear 2142, 2° A, C1122AAH Buenos Aires, Argentina;7. CONICET, Buenos Aires, Argentina, Godoy Cruz 2290, C1425FQB Buenos Aires, Argentina |
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| Abstract: | Selenium is an essential mineral element with important biological functions for the whole body through incorporation into selenoproteins. This element is highly concentrated in the thyroid gland. Selenoproteins provide antioxidant protection for this tissue against the oxidative stress caused by free radicals and contribute, via iodothyronine deiodinases, to the metabolism of thyroid hormones. It is known that oxidative stress plays a major role in carcinogenesis and that in recent decades there has been an increase in the incidence of thyroid cancer. The anti-carcinogenic action of selenium, although not fully understood, is mainly attributable to selenoproteins antioxidant properties, and to the ability to modulate cell proliferation (cell cycle and apoptosis), energy metabolism, and cellular immune response, significantly altered during tumorigenesis. Researchers have suggested that different forms of selenium supplementation may be beneficial in the prevention and treatment of thyroid cancer; however, the studies have several methodological limitations. This review is a summary of the current knowledge on how selenium and selenoproteins related to thyroid cancer. |
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| Keywords: | Selenium Selenoproteins Thyroid cancer Oxidative stress Supplementation |
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