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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
Affiliation:1. Obstetrics & Gynecology Hospital of Fudan University, Zhongshan Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China;2. Institute for Developmental and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;3. Department of Cardiothoracic Surgery, Second Hospital of Anhui Medical University, and Cardiovascular Research Center, Anhui Medical University, Hefei 230601, China;4. Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China;5. School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
Abstract:
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  • Keywords:heart failure  DNA damage response  protein tyrosylation  ATR  tyrosyl-tRNA synthetase  CP: Molecular biology
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