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TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
Affiliation:1. Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA;2. Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA;3. Department of Hematological Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA;4. City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA;5. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China;6. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;7. Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;8. Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA;9. Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA;10. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA;11. Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China;12. Department of Pediatrics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;13. Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;14. Department of Pathology, Harbin Medical University, Harbin 150081, China;15. Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31003, Zhejiang, China;16. State Key Laboratory of Medical Genomics, Clinical Trial Center, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract:
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  • Keywords:TET2  RNA 5-methylcytosine methylation  leukemia stem cell  homing  migration  self-renewal  bone marrow microenvironment  TSPAN13  CXCR4  YBX1
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