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Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain
Institution:1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA;3. Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA;4. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA;5. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;6. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;7. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;8. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
Abstract:
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  • Keywords:SARS-CoV-2  Omicron  booster immunization  antigen presentation  epitope masking  immunodominance  affinity maturation  vaccines  CP: Immunology
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