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Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
Institution:1. Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Brotman Building Room 453, Seattle, WA 98109, USA;2. Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA;3. Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA;4. Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195, USA;5. Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA;6. Sana Biotechnology, Seattle, WA 98102, USA;7. Department of Regenerative Science and Medicine, Shinshu University, Matsumoto 390-8621, Japan;8. Adaptive Biotechnologies, Seattle, WA 98102, USA;10. Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;11. Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Abstract:
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  • Keywords:human pluripotent stem cell-derived cardiomyocytes  cell therapy  heart regeneration  myocardial infarction  cardiac remuscularization  arrhythmia  engraftment arrhythmia  automaticity  pacemaker  hPSC-CM maturation
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