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Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency
Affiliation:1. Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2. Cancer Research UK Birmingham Centre, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;3. Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK;4. Centre for Computational Biology, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;5. Bioinformatics Research Technology Platform, University of Warwick, Coventry, UK
Abstract:
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  • Keywords:hematopoietic stem cells  zebrafish  GATA2 deficiency  single-cell genomics  DNA damage  CP: Molecular biology  CP: Stem cell research
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