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Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancer
Affiliation:1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea;2. Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul 03080, Korea;3. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea;4. Department of Pathology, Seoul National University Hospital, Seoul 03080, Korea;5. Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea;6. Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea;7. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea;8. IMBdx, Inc., Seoul 08506, Korea
Abstract:
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  • Keywords:colorectal cancer  3D cancer genome  structural variations  enhancer-hijacking  clonality  prognostic marker  CP: Cancer  CP: Genomics
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