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Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche
Affiliation:1. Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Departments of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA;3. Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA;4. Institute for Human Genetics and Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA;5. Department of Obstetrics, Gynecology and Reproductive Science and Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA;6. Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Abstract:
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  • Keywords:mesenchymal niche compartments  intestinal crypt structure and function  colonic crypts  intestinal Wnt source  trophocytes  PDGFRA+ mesenchymal cells  intestinal stem cell niche
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