Birth weight,adult body size,and risk of colorectal cancer |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN, USA;2. Department of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN, USA;3. Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA;4. Department of Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA;5. Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, NY, USA;6. Department of Medical Oncology, The Lundquist Institute, Torrance, CA, USA;7. Department of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA;8. Division of Epidemiology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA;1. Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA;2. Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA;1. Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan;2. Division of Epidemiology, Miyagi Prefectural Cancer Research Center, Natori, Japan;3. Miyagi Cancer Society, Sendai, Japan;1. National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;2. Health Technology Management Coordination, National Health Agency, Rio de Janeiro, Brazil;3. Department of Epidemiology and Quantitative Methods, National Public Health School, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;1. Leviev Heart Center, Sheba Medical Center, Ramat-Gan, Israel;2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel;3. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;4. The Institute of Nephrology and Hypertension, Sheba Medical Center, Ramat-Gan, Israel;5. The Institute for Medical Screening, Sheba Medical Center, Ramat-Gan, Israel;6. Department of Internal Medicine, Sheba Medical Center, Ramat-Gan, Israel;1. Department of Radiotherapy, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil;2. Department of Education and Research, Hospital de Câncer de Pernambuco, Recife, Pernambuco, Brazil;3. Department of Head and Neck Surgery, Hospital de Câncer de Pernambuco, Recife, Pernambuco, Brazil;4. Department of Oncology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil;5. Department of Pneumology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil;6. Clinical Research Division, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil;1. Department of Public Health Sciences, Clemson University, Clemson, SC 29634, USA;2. Center for Integrative Oncology & Survivorship, Prisma Health, 900 W Faris Rd 1st Floor, Greenville, SC 29605, USA;3. Clemson Center for Geospatial Technologies, Clemson University Libraries, 116 Sigma Drive, Clemson, SC 29634, USA |
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| Abstract: | BackgroundEvidence suggests that birth weight may be associated with colorectal cancer (CRC) risk later in life. Whether the association is mediated by adult body size remains unexamined.MethodCox proportional hazards models (Hazard Ratio (HR) and 95 % Confidence Intervals (CI)) were used to evaluate the association between self-reported birth weight (<6 lbs, 6-<8 lbs, ≥8 lbs) and CRC risk among 70,397 postmenopausal women from the Women’s Health Initiative. Further, we assessed whether this association was mediated by adult body size using multiple mediation analyses.ResultsCompared with birth weights of 6-< 8 lbs, birth weight ≥ 8 lbs was associated with higher CRC risk in postmenopausal women (HR = 1.31, 95 % CI 1.16–1.48). This association was significantly mediated by adult height (proportion mediated =11.4 %), weight (11.2 %), waist circumference (10.9 %), and body mass index at baseline (4.0 %). The joint effect of adult height and weight explained 21.6 % of this positive association.ConclusionOur data support the hypothesis that the intrauterine environment and fetal development may be related to the risk of developing CRC later in life. While adult body size partially explains this association, further investigation is required to identify other factors that mediate the link between birth weight and CRC. |
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| Keywords: | Birth weight Body size Body mass index Colorectal cancer |
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