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Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population
Affiliation:1. National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;2. National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;3. Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou 325101, Zhejiang, China;4. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China;5. Institute of PSI Genomics, Wenzhou 325024, China;6. Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100190, China;7. School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China;8. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China
Abstract:
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  • Keywords:high myopia  whole-exome sequencing  rare variants  exome-wide association study  burden test  CP: Genomics
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