Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study |
| |
| Affiliation: | 1. Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China;2. School of Public Health and Emergency Management, Southern University of Science and Technology, 1088 Xueyuan Street, Shenzhen 518055, China;1. Department of Internal Medicine, Jackson Memorial Hospital / University of Miami Health System, FL, USA;2. The Population Registry of Cancer of the Metropolitan Area of Bucaramanga, Universidad Autónoma de Bucaramanga, Colombia;3. Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogota, Colombia;4. University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, FL, USA;1. Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA;2. Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA;3. Cyberdata Technologies, Inc., Herndon, VA, USA;4. Division of Cancer Control and Population Sciences, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR, USA;5. Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA;6. John A Burns School of Medicine, University of Hawai‘i at Mānoa, Honolulu, HI, USA;7. Division of Chronic Disease and Prevention, US Virgin Islands Department of Health, St. Thomas, USVI, USA;1. CONACYT - Instituto Nacional de Cancerología, Mexico City, Mexico;2. Dirección de Investigación, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico;3. Dirección de Investigación, Instituto Nacional de Cancerología, Mexico City, Mexico;4. Departamento de Tumores Mamarios, Instituto Nacional de Cancerología, Mexico City, Mexico;5. Servicio de Oncología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico;6. Departmento de Tumores Ginecológicos, Instituto Nacional de Cancerología, Mexico City, Mexico;7. Departmento de Tumores Urológicos, Instituto Nacional de Cancerología, Mexico City, Mexico;8. Servicio de Urología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico;9. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cancerología, Mexico City, Mexico;1. Department of Epidemiology, Radiation Effects Research Foundation, 5-2, Hijiyama Park, Minami-ku, Hiroshima City, Hiroshima 732-0815, Japan;2. Division of International Health Policy Research, Institution for Cancer Control, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;3. Research Department, Fondazione IRCSS, Istituto Nazionale dei Tumouri, Via Venezian 1, 20133, Milan, Italy;1. Department of Mathematics and Statistics, Sam Houston State University, Huntsville, TX, USA;1. Department of Public Health, and Department of Endocrinology of the Children''s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children’s Health, Hangzhou 310058, China;2. Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;3. Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China |
| |
| Abstract: | BackgroundThe risk of hepatocellular carcinoma (HCC) is associated with a variety of factors. However, the possible association between the abnormal metabolism of fasting plasma glucose (FPG) and alanine aminotransferase (ALT) and the risk of HCC has not been widely studied. We examined this relationship based on a prospective cohort study.Methods162 first-attack HCC cases during three follow-up periods (2014–2020) were selected as the case group. A control group of 648 participants was obtained by 1:4 matching of age (± 2 years) and sex with noncancer participants in the same period. Conditional logistic regression models, restricted cubic spline models, additive interaction models, and generalized additive models were used to explore the effects of FPG and ALT on the risk of HCC.ResultsAfter correction for confounding factors, we found that abnormal FPG and elevated ALT increased the risk of HCC, respectively. Compared with the normal FPG group, the risk of HCC was significantly increased in the impaired fasting glucose (IFG) (OR = 1.91, 95 %CI: 1.04, 3.50) and diabetes groups (OR = 2.12, 95 %CI: 1.24, 3.63). Compared with the lowest quartile of ALT, subjects in the fourth quartile had an 84 % increased risk of HCC (OR = 1.84, 95 %CI: 1.05–3.21). Moreover, there was an interaction between FPG and ALT on the risk of HCC, and 74 % of the HCC risk could be attributed to their synergistic effect (AP = 0.74, 95 %CI: 0.56–0.92).ConclusionAbnormal FPG and elevated ALT are independent risk factors for HCC, and they have a synergistic effect on the risk of HCC. Therefore, serum FPG and ALT levels should be monitored to prevent the development of HCC. |
| |
| Keywords: | Alanine aminotransferase Cohort study Fasting plasma glucose Hepatocellular carcinoma Interaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
