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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis
Affiliation:1. Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA;2. Division of Hematology and Medical Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA;3. Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA;4. Division of Digestive and Liver Diseases, Columbia Center for Human Development, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA;5. Division of Hematopathology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA
Abstract:
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  • Keywords:LepR  Gli1  myelofibrosis  hematopoietic stem cells  mesenchymal stromal cells  microenvironmental niche  lineage tracing  single-cell RNA sequencing  glial cells
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