Prevalence and factors associated with atrophic gastritis and intestinal metaplasia: A multivariate,hospital-based,statistical analysis |
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| Affiliation: | 1. Gastrohepatology Unit, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;2. Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;3. Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;4. Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand;1. Belgian Cancer Registry, 1210 Brussels, Belgium;2. Family Medicine and Population Health, Department of Epidemiology and Social Medicine, University of Antwerp, 2000 Antwerp, Belgium;3. Centre for Cancer Detection, 8000 Bruges, Belgium;4. Vrije Universiteit Brussel, 1090 Brussels, Belgium;5. University Hospital Leuven, Campus Sint Rafael, 3000 Leuven, Belgium;6. Agency for Care and Health, Flemish Government, 1030 Brussels, Belgium;7. Christian Health Insurance Fund, 1031 Brussels, Belgium;8. Department of Public Health and Primary Care, Environment and Health, KU Leuven, 3000 Leuven, Belgium;9. Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands;1. Univ. Bordeaux, Gironde General Cancer Registry, 33000 Bordeaux, France;2. Inserm, Bordeaux Population Health, Research Center U1219, Team EPICENE, 33000 Bordeaux, France;3. Centre Régional de Coordination du Dépistage des Cancers (CRCDC), Nouvelle Aquitaine, France;4. Loire-Atlantique/Vendée Cancer Registry, Nantes, France;5. CERPOP, Université de Toulouse, Toulouse, France;6. FRANCIM Network of French Cancer Registries, France;7. Breast and Gynaecologic Cancer Registry of Côte d’Or, Georges Francois Leclerc Comprehensive Cancer Centre, INSERM U1231, 1 rue Professeur Marion, Dijon, France;8. Epidemiology and Quality of Life Research Unit, INSERM U1231, Dijon, France;9. Institut Bergonie, Inserm CIC 1401, Clinical and Epidemiological Research Unit, 351 cours de la Libération, 33405 Talence cedex, France;1. Max Planck Institute for Demographic Research, Rostock, Germany;2. School of Public Health, Chongqing Medical University, Chongqing, China;3. Department of Medical Sciences, University of Turin, Turin, Italy;4. Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland;1. Department of Gastroenterology, Mater Misericordiae University Hospital, Dublin, Ireland;2. School of Medicine, University College Dublin, Ireland;3. Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland;4. Department of Pathology, Mater Misericordiae University Hospital, Dublin, Ireland;5. Department of Pathology, St Vincent’s University Hospital, Dublin, Ireland;6. Department of Colorectal Surgery, St Vincent’s University Hospital, Dublin, Ireland;1. Hungarian National Cancer Registry and National Tumorbiology Laboratory, National Institute of Oncology, Budapest, Hungary;2. Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France;3. Department of Molecular Immunology and Toxicology and National Tumorbiology Laboratory, National Institute of Oncology, Budapest, Hungary |
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| Abstract: | BackgroundAtrophic gastritis (AG) and intestinal metaplasia (IM) play an essential role in gastric carcinogenesis. This study aimed to determine the prevalence of AG and IM and their associated factors.MethodsSubjects who underwent upper endoscopy at Chiang Mai University Hospital from January 2018 to Dec 2021 were included. All participants were interviewed using a structured questionnaire to collect their personal histories. In addition, clinical and histological data and associated factors of AG and IM were analyzed.ResultsA total of 947 subjects (mean age, 53.61 ± 9.73 years; 60% male) were included. The prevalence of AG and IM, diagnosed by histopathology, was 39% and 19%. Prevalence of AG and IM increased from 28% and 9% in those under 50 years to 43% and 30% in those above 60 (p < 0.05). In a multivariate analysis, Helicobacter pylori (H. pylori) infection, age 50–59 and over 60 years were significantly associated with higher odds of AG (odds ratio (OR), 2.07, 2.06, and 1.98) and IM (OR, 2.07, 2.18, and 4.46), respectively. Conversely, ingestion of spicy food was significantly associated with lower odds of AG and IM (OR, 0.75, and 0.62).ConclusionsThis study confirms that age and H. pylori infection are risk factors, whereas spicy food intake is a protective factor against AG and IM, which are common in patients over 50. Therefore, upper endoscopy and gastric mapping sampling are recommended for patients with chronic dyspepsia older than 50 to reduce gastric cancer risk. |
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| Keywords: | Age Atrophic gastritis Intestinal metaplasia Spicy food |
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