Higher blood selenium level is associated with lower risk of hyperhomocysteinemia in the elderly |
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| Affiliation: | 1. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China;2. School of Public Health, Guizhou Medical University, Guiyang 550025, China;3. Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China;4. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA;5. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA;6. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202–2872, USA |
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| Abstract: | Background and aimsEarlier studies have reported inconsistent association between selenium (Se) and homocysteine (Hcy) levels, while no evidence could be found from Chinese population. To fill this gap, we investigated the association between blood Se and hyperhomocysteinemia (HHcy) of rural elderly population in China.MethodsA cross-sectional study on 1823 participants aged 65 and older from four Chinese rural counties was carried out in this study. Whole blood Se and serum Hcy concentrations were measured in fasting blood samples. Analysis of covariance and restricted cubic spline models were used to examine the association between Se and Hcy levels. Logistic regression models were used to evaluate the risk of prevalent HHcy among four Se quartile groups after adjusting for covariates.ResultsFor this sample, the mean blood Se concentration was 156.34 (74.65) μg/L and the mean serum Hcy concentration was 17.25 (8.42) μmol/L. A significant non-linear relationship was found between blood Se and serum Hcy, the association was inverse when blood Se was less than 97.404 μg/L and greater than 156.919 μg/L. Participants in the top three blood Se quartile groups had significantly lower risk of prevalent HHcy compared with the lowest quartile group. When defined as Hcy> 10 μmol/L, the odds ratios and 95% confidence interval of HHcy were 0.600 (0.390, 0.924), 0.616 (0.398, 0.951) and 0.479 (0.314, 0.732) for Q2, Q3, and Q4 Se quartile groups compared with the Q1 group, respectively. When defined as Hcy≥ 15 μmol/L, the odds ratios and 95% confidence interval of HHcy were 0.833 (0.633, 1.098) and 0.827 (0.626, 1.092), 0.647 (0.489, 0.857) for Q2, Q3, and Q4 Se quartile groups compared with Q1 group.ConclusionsOur findings suggest that higher blood Se level could be a protective factor for HHcy in the elderly. |
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| Keywords: | Blood selenium Homocysteine Hyperhomocysteinemia Elderly Chinese Risk assessment Selenium" },{" #name" :" keyword" ," $" :{" id" :" key0035" }," $$" :[{" #name" :" text" ," _" :" Se Homocysteine" },{" #name" :" keyword" ," $" :{" id" :" key0045" }," $$" :[{" #name" :" text" ," _" :" Hcy Hyperhomocysteinemia" },{" #name" :" keyword" ," $" :{" id" :" key0055" }," $$" :[{" #name" :" text" ," _" :" HHcy Cardiovascular disease" },{" #name" :" keyword" ," $" :{" id" :" key0065" }," $$" :[{" #name" :" text" ," _" :" CVD Body Mass Index" },{" #name" :" keyword" ," $" :{" id" :" key0075" }," $$" :[{" #name" :" text" ," _" :" BMI Inductively-coupled plasma mass spectrometry" },{" #name" :" keyword" ," $" :{" id" :" key0085" }," $$" :[{" #name" :" text" ," _" :" ICP-MS Randomized controlled trials" },{" #name" :" keyword" ," $" :{" id" :" key0095" }," $$" :[{" #name" :" text" ," _" :" RCTs Analysis of variance" },{" #name" :" keyword" ," $" :{" id" :" key0105" }," $$" :[{" #name" :" text" ," _" :" ANOVA Analysis of convariance" },{" #name" :" keyword" ," $" :{" id" :" key0115" }," $$" :[{" #name" :" text" ," _" :" ANCOVA Odds ratio" },{" #name" :" keyword" ," $" :{" id" :" key0125" }," $$" :[{" #name" :" text" ," _" :" OR Confidence intervals" },{" #name" :" keyword" ," $" :{" id" :" key0135" }," $$" :[{" #name" :" text" ," _" :" CI Metabolism of methionine" },{" #name" :" keyword" ," $" :{" id" :" key0145" }," $$" :[{" #name" :" text" ," _" :" Met Cysteine" },{" #name" :" keyword" ," $" :{" id" :" key0155" }," $$" :[{" #name" :" text" ," _" :" Cys Betaine-Hcy methyltransferase" },{" #name" :" keyword" ," $" :{" id" :" key0165" }," $$" :[{" #name" :" text" ," _" :" BHMT Methionine synthase" },{" #name" :" keyword" ," $" :{" id" :" key0175" }," $$" :[{" #name" :" text" ," _" :" MS Cystathionine synthase" },{" #name" :" keyword" ," $" :{" id" :" key0185" }," $$" :[{" #name" :" text" ," _" :" CBS |
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