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Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
Affiliation:1. Department of Neurology, UMass Chan Medical School, Worcester, MA 01605, USA;2. Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA, USA;3. Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA;4. Division of Infectious Diseases and Immunology, Department of Medicine, UMass Chan Medical School, Worcester, MA 01605, USA
Abstract:
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  • Keywords:ALS  antimicrobial peptide  C9ORF72  FTD  DPR  Hsp90  poly(GR)  TopoII  Mtk  neurodegeneration
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