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Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
Affiliation:1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;2. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;3. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China;4. Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China;5. Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China;6. University of Chinese Academy of Sciences, Beijing 100049, China;7. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China;8. Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;9. The Fifth People’s Hospital of Chongqing, Chongqing 400062, China;10. Altos Labs, Inc., San Diego, CA, USA;11. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;12. Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China;13. Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China;14. Beijing Neurosurgical Institute, Beijing 100070, China;15. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;16. Chinese Glioma Genome Atlas Network & Asian Glioma Genome Atlas Network, Beijing 100070, China;17. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;18. Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China;19. Clinical Research Center for Epilepsy Capital Medical University, Beijing 100053, China;20. Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China;21. MAIS, State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;22. School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China;23. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing 100871, China;24. Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing 100191, China;25. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China;26. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing 400042, China;27. State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Abstract:
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  • Keywords:nuclear lamina  endogenous retroviruses  brain  aging  inflammation  CP: Neuroscience  CP: Cell biology
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