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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination
Affiliation:1. Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK;2. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK;3. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK;4. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK;5. Beijing You’an Hospital, Capital Medical University, Beijing 100069, China;6. Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK;7. Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK;8. Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand;9. Genome Engineering Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK;10. Screening Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK;11. Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK;12. Sequencing Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK;13. Pandemic Sciences Institute, University of Oxford, Oxford, UK;14. National Institute for Health Research Oxford Biomedical Research Center, Oxford, UK
Abstract:
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  • Keywords:SARS-CoV-2  variants of concern  spike protein  T cell  antigen processing and presentation  immune escape  recombinant vaccinia virus  ChAdOx1 nCoV-19  CP: Immunology
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