G protein-coupled receptors in cardiac biology: old and new receptors |
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| Authors: | Simon R Foster Eugeni Roura Peter Molenaar Walter G Thomas |
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| Institution: | 1.School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072 Brisbane, Australia ;2.Centre for Nutrition & Food Sciences, Queensland Alliance for Agriculture and Food Innovation, University of Queensland, St Lucia Campus, Brisbane, Australia ;3.Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, St Lucia Campus, Brisbane, Australia ;4.School of Medicine, University of Queensland, St Lucia Campus, Brisbane, Australia |
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| Abstract: | G protein-coupled receptors (GPCRs) are seven-transmembrane-spanning proteins that mediate cellular and physiological responses. They are critical for cardiovascular function and are targeted for the treatment of hypertension and heart failure. Nevertheless, current therapies only target a small fraction of the cardiac GPCR repertoire, indicating that there are many opportunities to investigate unappreciated aspects of heart biology. Here, we offer an update on the contemporary view of GPCRs and the complexities of their signalling, and review the roles of the ‘classical’ GPCRs in cardiovascular physiology and disease. We then provide insights into other GPCRs that have been less extensively studied in the heart, including orphan, odorant and taste receptors. We contend that these novel cardiac GPCRs contribute to heart function in health and disease and thereby offer exciting opportunities to therapeutically modulate heart function. |
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| Keywords: | G protein-coupled receptor Heart Cardiovascular disease Orphan receptor Odorant receptor Taste receptor |
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