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Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal
Institution:1. Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;2. Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;3. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;4. Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;5. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA;6. Graduate Program in Cancer and Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;7. Graduate Program in Immunology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;8. McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;9. Department of Breast Medical Oncology and Morgan Welch IBC Research Program and Clinic, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;10. University of Hawai’i Cancer Center (UHCC), 701 Ilalo Street, Honolulu, HI 96813, USA;11. Departments of Laboratory Medicine and Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan;12. School of Medicine, College of Medicine, China Medical University, Taichung 406, Taiwan;13. Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan;14. Division of Breast Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan;15. Immunomonitoring Core, Center for Immunotherapy Research, Houston Methodist Research Institute (HMRI), Houston, TX, USA;16. Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University, Taichung 40402, Taiwan
Abstract:
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  • Keywords:cancer  hematopoietic stem/progenitor cells  systemic immunosuppression  MDSCs  hematopoiesis  bone marrow niches  immunotherapies  osteoprogenitor  myelopoiesis  scRNA-seq
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