Clinical and biochemical understanding of Zinc interaction during liver diseases: A paradigm shift |
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| Institution: | 1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China;2. Hebei Key Laboratory of Reproductive Medicine, Hebei Institute of Reproductive Health Science and Technology, Shijiazhuang 050071, China;1. Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestr. 9-11, Erlangen, Germany;2. Independent Researcher, Richardstr. 35, Bochum, Germany;1. College of Mechanical Engineering, & National Consortium for Excellence in Metallomics, Guangxi University, Nanning, Guangxi 530004, China;2. CAS-HKU Joint Laboratory of Metallomics on Health and Environment, & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, & Beijing Metallomics Facility, & National Consortium for Excellence in Metallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;1. College of Life Sciences, Changchun Sci-Tech University, Changchun 130600 China;2. Changchun Academy of Agricultural Science, Changchun 130062 China;3. Health Monitoring and Inspection Center of Jilin Province, Changchun 130062 China;4. Bureau of Agriculture and Rural Affairs of Wangqing County, Yanbian 133200 China;1. Department of Chemistry, Institute of Science, Dicle University, 21280 Diyarbakir, Turkey;2. Department of Medical Pharmacology, Faculty of Medicine, Yozgat Bozok University, 66000 Yozgat, Turkey;3. Department of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, 24002, Erzincan, Turkey;4. Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, 21280 Diyarbakir, Turkey;5. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Düzce University, 81620 Düzce, Turkey;6. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06570 Ankara, Turkey |
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| Abstract: | Zinc (Zn) is an essential and the second most abundant trace element after Iron. It can apply antioxidant, anti-inflammatory, and anti-apoptotic activity. It is assumed to be indispensable for cell division, cellular differentiation and cell signalling. Zinc is essential for proper liver function which is also the site of its metabolism. Depleted Zn concentrations have been observed in both acute and chronic hepatic diseases. It is reported that Zn deficiency or abnormal Zn metabolism during majority of liver diseases is attributed to deficient dietary intake of Zn, augmented disposal of Zn in the urine, activation of certain Zn transporters, and expression of hepatic metallothionein. Undoubtedly, Zn is involved in generating many diseases but how and whether it plays role from acute to fulminant stage of all chronic liver diseases remains to be cleared. Here, we will discuss the role of Zn in development of different diseases specifically the involvement of Zn to understand the aetiology and intricate mechanism of dynamic liver diseases. |
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| Keywords: | Drug induced liver disease HCC Hypoalbuminaemia Liver fibrosis Metallothionine Zinc Zn transporters |
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