Vanadium compounds as antiparasitic agents: An approach to their mechanisms of action |
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| Institution: | 1. Av. Ciudad Universitaria 3000, C.P. 04510, Coyoacan, Mexico City, Mexico;2. Department of Cellular and Tissue Biology, School of Medicine, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;3. Posgrado en Ciencias Biologicas, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;4. Department of Microbiology and Parasitology. School of Medicine, UNAM, C.P. 04510, Coyoacan, Mexico City, Mexico;1. Department of Sport Physiology, Shahrood Branch, Islamic Azad University, Shahrood, Iran;2. Department of Medical Sciences, Biological Nanoparticles in Medicine Research Center, Shahrood Branch, Islamic Azad University, Shahrood, Iran;3. Department of Sport Sciences, Faculty of Human Sciences, Damghan University, Semnan, Iran;4. Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran;1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Immunology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran;3. University of Debrecen, Medical School Hungary, Egyetem tér 1, Debrecen;4. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India;7. Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai 602105, India;8. University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India;9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;11. School of Medicine, The University of Western Australia, Perth, Australia;12. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Animal and Poultry Nutrition, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Iran;2. Department of Animal Science, faculty of Agriculture, University of Tabriz, Iran;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1417DSM Ciudad Autónoma de Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Salud Pública, Av. Chorroarín 280, C1427CWO Ciudad Autónoma de Buenos Aires, Argentina;3. Centro de Estudios Transdisciplinarios de Epidemiología (CETE), Universidad de Buenos Aires, Argentina;1. Department of Chemistry, Punjabi University, Patiala, Punjab, India;2. Department of Chemistry, Patel Memorial National College, Punjab, India |
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| Abstract: | BackgroundParasitic infections are a public health problem since they have high morbidity and mortality worldwide. In parasitosis such as malaria, leishmaniasis and trypanosomiasis it is necessary to develop new compounds for their treatment since an increase in drug resistance and toxic effects have been observed. Therefore, the use of different compounds that couple vanadium in their structure and that have a broad spectrum against different parasites have been proposed experimentally.ObjectiveReport the mechanisms of action exerted by vanadium in different parasites.ConclusionIn this review, some of the targets that vanadium compounds have were identified and it was observed that they have a broad spectrum against different parasites, which represents an advance to continue investigating therapeutic options. |
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| Keywords: | Vanadium Action mechanisms Malaria Leishmaniasis trypanosomiasis Metallic compounds |
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