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NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer
Affiliation:1. Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China;2. Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;3. Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China;4. Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China;5. Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China;6. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China;7. Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea;8. Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea;9. Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul 04763, Republic of Korea;10. Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea
Abstract:
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  • Keywords:NAT10  N4-acetylcytidine  EGFR  esophageal cancer  tRNA modificatio  CP: Cancer
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